I played MYZ twice last year in a convention and it worked really well.
Our Game-master gave us some pre generated Mutants, and during the first session started a project (if i remember properly, it was reinforce our Ark's protection; we used bones corpes on my idea) and explored the Zone almost bonding with foes (i do think now that she (the GM) change a bit the lore of the game for what the foe, we initially fought, were).
The second session was a bit different, first it was a multi-table, and secondly it was a cross over with Call Of Cthulhu. For the most part it worked as much as the first session above. For the crossover itself, what merged the game together was an artifact actually if someone touched it, she•he was bodyswaped with a PC from Cthulhu. The body remains the same in both game but his•her soul/personality is from the other game. It was quite funny, really good idea and worked really good. Specially with me, as i also played a Cthulhu game during the con with the same GM, and the game we played was actually the prequel of that multi-table, so i knew exactly we were more or less screwed during the 2nd session of Mutant when we discovered a room in a building during our exploration. So basically some meta-game in it ^^.
The GM was so bored (in a funny way) seeing me each time, but each time i played with her, she use some wonderful ideas how to resist ? (Like on another Cthulhu game in a previous year of that con, we were member of a "circus" (think AHS Freakshow), and in the end we discovered the circus was not a real one but a environment designed for us as we were in fact test subject for some Lovecraftian god and it was not in the '20 but in our current period of time).
So yeah, in short the game work really well in convention. In the end, rules are only rules, what matters are the stories.