In chapter 6 on page 144, you reference the Nexus-6 as having a "positronic brain" which is lore-breaking. Asimov conceived the positronic brain as something electronic and robotic in nature, made of platinum and iridium. The Nexus-6 are fully organic beings. The inclusion of this term implies that the Nexus-6 are robots, not organic, which completely dismantles the central theme of the films.
This term is also referenced for Nexus 1-5 models on page 142, as is the term "artificial intelligence." My understanding of pre-established lore is that every generation of replicant was conceived as a fully organic, bioengineered beings with organic brains. How exactly would someone program "artificial intelligence" into an organic brain? This is why memories were used to control replicants in the first place, because they couldn't be programmed with AI. The reference to positronic brains and artificial intelligence would absolutely make sense for pre-Nexus robotic automotons, but it feels like using these terms to refer to replicants is redefining what these beings are from what we see in the films.