The two Bladerunner movies are neo noir movies set in L. A. It’s a very specific genre based premise. What genre would be used in an off-world supplement? Of course, you can imagine someone like Deckard leaving Earth for some kind of mission, but would it be cool? Would it still feel like a Bladerunner movie? I don’t think so. I’d rather say that a neo noir L. A. is the setting. If you go off-world, you go off genre and then you would have to reinvent the entire setting. Problematic.
It's been suggested that the movie "Outland" is in the same universe as "Alien" and "Bladerunner". Outland is basically about a lawman going to a mining colony on one of Jupiter's moons to act as its "town marshal" so to speak. Free League have already said that scenario "cases" need not necessarily involve Replicants so I can certainly see the opportunity for some noir detective work on an Off-World Colony like that seen in the movie "Outland".