Here are issues (some problems, others things to to consider; some minor, others major) with the franchise, and they might or might have an effect on RPG versions:
Mother may or may not have been calling the shots. It can't be the former because Dallas was the captain of the ship, and the only one who could order him to do things like re-route the ship would have been Weyland-Yutani (WY), the company that owns the Nostromo. That means Mother was in periodic contact with WY throughout, which is also what WY would have wanted because the distress signal was equivalent to finding intelligent life, which is similar to finding an alien craft on earth. But if that were the case, then WY would have known enough about the alien, including the coordinates of the beacon. That means WY wouldn't have needed to get them from the lifeboat flight recorder that carried Ripley.
After the facehugger dropped off Kane, Dallas told Ripley (who questioned Ash's question) that he doesn't know Ash that much because Ash replaced their original science officer only recently. Usually, writers add these small details because they are important. This might imply that the company knew about the aliens and the beacon before the Nostromo launched from the port where Ash replaced the science officer.
Ripley later tells the others that Ash followed the special order she discovered from Mother because WY wanted to use the organism for its bio-weapons division. The formation of such a division implies that WY was preparing to exploit such organisms, and probably even this specific one, early on.
During the whole time that WY had the coordinates (if it did get them from Mother, which it would have naturally asked for), it did not bother to investigate the location of the beacon (whether or not it went offline for any reason, either through volcanic activity according to Cameron or turned off according to the Isolation game) during the decades that they didn't hear from the Nostromo and when they even built a colony on the same rock.
Ripley's hearing in the second movie was strange: the only thing that could have proved her story and thus her innocence were checking the coordinates of the distress beacon given in the flight recorder. But for some absurd reason the ICC and ECA refused to honor her request to investigate them; isn't the accused innocent until proven guilty? Also, wasn't that supposed to be a board of inquiry and not one involving prosecution?
We're not sure how much information the colony gave to WY, but if the transmitter went down due to an alien attack, then that means WY knew more than enough, but probably assumed that only two aliens were involved (given two dead facehuggers, and the other two extracted alive but killing their human hosts). That's why they sent only one squad, because they thought with two aliens and over a hundred colonists, the job of killing few aliens would have been easy, especially with armaments they were carrying. Also, WY knew the location of the derelict ship, which made getting the facehuggers not that important because there were still hundreds of eggs in the alien craft (according to Ripley, as reported to her by Dallas, Kane, and Lambert) that they could exploit.
Why didn't the Sulaco have a captain and a crew? Surely, something equivalent to a capital ship and nuclear-armed (later, the survivors wanted to destroy the colony with a nuclear strike to end the suffering of those left behind and cocooned by the aliens) would have had that. But that would have ruined the storyline of the second movie because one of the difficulties they encountered was not having anyone onboard to send down a second dropship. Also, didn't Gorman tell Ripley that she wouldn't get into harm's way because she'd be onboard the Sulaco instead of on the ground?
It also looks absurd and un-military: having no captain and crew, no one aboard the orbiting ship, no backup transmitters, no fortified command post to conduct operations, etc. Even WY looked incompetent, with the colony having no backup transmitter, too.
In the third movie, after he was re-activated Bishop told Ripley that WY knows everything because the Sulaco computer was feeding them everything that was going on in the ship. That's why WY knows about the embryo inside Ripley. Why is a military computer feeding information to a private company? Does this imply collusion between the two?
Also, was the derelict ship destroyed by the nuclear blast caused by the colony reactor? If so, then that explains why WY needed to capture the alien in the prison as well as the one inside Ripley's body. But if not, then the third movie would have looked unnecessary because the company could have retrieved the eggs and more from the derelict ship.
Some more issues, but they are based more on opinions: first, Ripley turns from a tough-minded blue collar worker (she's a flight officer, but of a towing vessel, which makes her and others the equivalent of space truckers) to an action hero and leader all of a sudden. Also, when the Nostromo crew and even the board find out about the derelict ship, they don't seen excited about it. Wouldn't you be if you found an alien craft with what should be advanced technology? It'd be similar to finding a gold mine.
Lastly, several media licensed by the company resolve some of these issues but create new ones. For example, some explain that the company set up a bio-weapons division, special orders to capture aliens, changed the Nostromo science officer, and re-routed the ship after partially decoding the signal which indicated not distress but a warning, because of what happened in the prequels. The reason why the ICC and ECA did not honor Ripley's request to check the coordinates was because WY scrubbed the coordinates from the flight recorder. And not just the colony but even Burke was sending messages to WY and others. Meanwhile, the Isolation game shows that another ship found the derelict ship and caused infestation to spread to a space station between the first and second movies.