I am not running a Blade Runner campaign at the moment - Blade Runner stands in for Earth in the Alien setting for me.
But, if I were to run a Blade Runner campaign today, some of what I would want to sort out includes:
A Cast of NPCs
To me, the biggest requirement for anything Blade Runner is a large cast of NPCs.
Look at the movies - every scene is a role interaction really.
Even Deckard and Leon's fight is more verbal interaction than physical action (mostly Leon...)
A good system to generate lots of different NPCs quickly seems like the main thing you'd want.
Free League's Twilight 2000 Referee's Manual also has an NPC Motivations generator in the solo rules section pp104-105
RoleplayingTips.com has a "3-line NPC method" that can help with this: Think of an Appearance, Portrayal, and Hook/Secret for each NPC.
https://www.roleplayingtips.com/rptn/th ... npcs-fast/
And there are tons of "sci-fi" and "cyberpunk" NPC appearance generators on the web. Bookmark some and keep them in a handy "GM Tools" folder in your bookmark toolbar.
Factions Factions Factions
I would want at least a handful of "street-level" factions - pure criminals and rebels - the underworld
a handful of "middle class" factions - this includes your typical cyberpunk types - cops, blade runners, small businesses, etc - your traditional governments and their agents could go here too as their power has been eclipsed by corporations and offworld colonies.
a handful of "elite" factions - the megacorps - all trying to take or keep control, do shady things for money, etc...
Groups of NPCs become factions and you can play them against each other as story/plot background to create deeper world immersion notes for your players.
Cultures Cultures Cultures
Earth Reclaimers vs Offworld Colonials, Replicants vs Humans, you could even thrown in Alien style androids vs. Blade Runner style Replicants
Ticking Clocks
Plan a series of world-shaking events - such as one a month - that happen regardless of the players activities.
Mine out news headlines for stuff you think sounds like it could happen in the world of Blade Runner: wars start and end, new inventions, serial crimes etc.
Kick off one of these story events roughly each game month to change the background theme and tone a bit as your campaign goes.
A little hope this month, a bit more despair that month, smooth sailing some month, rough sailing the next month, etc.
And my final general tip:
Run your own GM Solo game for yourself *in* your Blade Runner campaign.
Playing your own character "somewhere else" in the same story as the players can be a great way to tap into the creativity.
The things you create or do for your solo game can also become more "game pieces" to re-use with the players' game.
We live, as we dream -- alone. ~ Joseph Conrad