Thu 09 Feb 2023, 23:11
Really the best advice for running the game are on pages 4-11 of the Gamemaster's Guide. Follow the advice therein and you should be good to go.
One thing I found is that if your players play cautiously and smart, this game is not as lethal as it seems. Also, you as GM can make the world grimmer or less grim by adjusting the tone of encounters with NPCs and all the other things you portray. Only you will know what you and your players will enjoy. Figure that out, discuss it at the table and apply!
I hope this helps.