That's something I was thinking the other day, Valarian. It's interesting that RPGs are designed to play in person, and therefore avoiding cumbersome calculations and bookkeeping is a main factor in design.Simpler for in-person games. It's likely to make things more complicated for VTT rolls.... and it also makes calculations simpler. You don’t have to recalculate the TN, simply remove a die or two from your hand.
But VTTs take care of that, so there could (at some point) be RPGs designed for online playing that don't care about complex calculations.
Might there be a different market for online and P2P gaming at some point?