I haven't played this yet (other than by myself a little bit), but games in the Year Zero family are very use friendly and easy to learn, sure T2K v4 are a bit more complex and crunchier than the average YZE-game, but still not so hard. As soon as everyone has learned the basics of the game it will flow just fine, even with 6 players. One thing that can be a thing in many games with many players is combat, but since this game uses battle maps and tokens (or minis if you have that) as default, that will certainly makes life at lot easier. I used battle maps in other YZE-games (for bigger battles) and it creates a better flow of the combat. I am not an expert in VTT, but what I have seen, it can work well, if everyone knows it (something that I haven't seen much yet, but it is new so), but I think the game will work very well or even better around a real table with the players there. One issue that has nothing to do with this game is that with a large group, it can be tricky to let all the players shine.
“Thanks for noticin' me.” - Eeyore